Cheng‐Wei Ju

Lineage tracing reveals asynchronous fate restriction in mouse embryos and stem cell-derived embryo models

The paper uses lineage tracing to show that fate restriction in mouse embryos and stem cell-derived models is asynchronous and not solely determined by cell identity.

A U1-U3 snRNA-snoRNA interaction couples SF3B1 mutation to chromatin-state rewiring and genome instability

This paper identifies a U1-U3 snRNA-snoRNA interaction that links SF3B1 mutations to chromatin-state changes and genome instability, with therapeutic potential through antisense oligonucleotides.

Complexoform-restricted covalent TRMT112 ligands that allosterically agonize METTL5

The paper develops covalent ligands that specifically target a complexoform of TRMT112, revealing partner-specific functional effects through allosteric activation of METTL5.

Quantifying Protein-Protein Interaction with a Spatial Attention Kinetic Graph Neural Network

SAKE-PP improves PPI model evaluation by predicting interface RMSD without native references, outperforming AF3 on docking decoys and antibody-antigen complexes.

ChemXTree: A Tree-enhanced Classification Approach to Small-molecule Drug Discovery

ChemXTree improves small-molecule drug discovery by integrating tree-based algorithms with a graph model, showing superior performance in feature optimization on benchmark datasets.