Cohesin modulates DNA replication to preserve genome integrity
Jinchun Wu, Yang Liu, Zhengrong Zhangding, Xuhao Liu, Ai Chen, Tingting Gan, Yiyang Liu, Jianhang Yin, Weiwei Zhang, Jiazhi Hu
This study shows that cohesin coordinates DNA replication initiation to maintain proper replication timing and genome integrity by affecting dormant origin firing and preventing DNA breaks and translocations.
bioRxiv · Dec 6, 2021 · PreprintGenetics