Author

Ai Chen

Peking UniversityORCID 0000-0002-5682-2148Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:variant calling· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:CRISPR screen· 1

Frequent Co-Authors

Jianhang Yin· 2 shared Jiazhi HuiD· 2 shared Chang CheniD· 1 shared Chang Liu· 1 shared Changchang XiniD· 1 shared Chuyan Shi· 1 shared Fei‐Long MengiD· 1 shared Fenghui Zhuang· 1 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersGenetics

Jianhang Yin

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

STEAP4+ neutrophils: a promising circulating biomarker for lung metastasis

Ai Chen, Huijuan Wu, huihui Yang, Jing Wang, Chang Liu, Melissa S.F. Ng, Ziheng Zhou, Fenghui Zhuang, Qinhang Gao, Lingqian Wang, Chuyan Shi, Linnan Zhu, Zhaode Bu, Chang Chen, Lai Guan Ng, Zemin Zhang

The paper identifies STEAP4+ neutrophils as a circulating biomarker for lung metastasis, validated in both human and mouse models.

bioRxiv · Dec 27, 2025 · PreprintCancer Biology

Cohesin modulates DNA replication to preserve genome integrity

Jinchun Wu, Yang Liu, Zhengrong Zhangding, Xuhao Liu, Ai Chen, Tingting Gan, Yiyang Liu, Jianhang Yin, Weiwei Zhang, Jiazhi Hu

This study shows that cohesin coordinates DNA replication initiation to maintain proper replication timing and genome integrity by affecting dormant origin firing and preventing DNA breaks and translocations.

bioRxiv · Dec 6, 2021 · PreprintGenetics

Global detection of DNA repair outcomes induced by CRISPR-Cas9

Mengzhu Liu, Weiwei Zhang, Changchang Xin, Jianhang Yin, Yafang Shang, Ai Chen, Jiaxin Li, Fei‐Long Meng, Jiazhi Hu

The paper develops an in silico pipeline to analyze CRISPR-Cas9-induced DNA repair outcomes, identifying deleterious byproducts like large deletions and chromosomal translocations.

Nucleic Acids Research · Jul 27, 2021Peer-reviewedGenomics