Jinchun Wu

Transfer of mitochondrial DNA into the nuclear genome during gene editing

This study shows that genome editing can transfer mitochondrial DNA into the nuclear genome, and provides a solution using TREX1 or TREX2 exonucleases.

Cohesin modulates DNA replication to preserve genome integrity

This study shows that cohesin coordinates DNA replication initiation to maintain proper replication timing and genome integrity by affecting dormant origin firing and preventing DNA breaks and translocations.

Oscillatory cortical forces promote three dimensional cell intercalations that shape the mandibular arch

The paper shows that oscillatory cortical forces drive 3D cell intercalations in the mouse mandibular arch, shaping embryonic structures through Wnt5a, YAP/TAZ, and PIEZO1.