Zhengrong Zhangding

The paper introduces Fun2, a reinforcement learning-based algorithm to characterize trajectory-like chromatin architectures, including fountains and stripes, with improved adaptability and accuracy.

This study shows that genome editing can transfer mitochondrial DNA into the nuclear genome, and provides a solution using TREX1 or TREX2 exonucleases.

This study shows that cohesin coordinates DNA replication initiation to maintain proper replication timing and genome integrity by affecting dormant origin firing and preventing DNA breaks and translocations.