Hepatic fructose metabolism is antagonized by growth hormone/insulin-like growth factor signaling via regulation of ketohexokinase expression
Salaheldeen Elsaid, Prathibha Meesala, Youngshim Choi, Liqing Yu, Yang Xiao, Mitchell A. Lazar, Patricia Pérez‐Matute, Edward Owen List, Lanuza A.P. Faccioli, Yiyue Sun, Rodrigo Machado Florentino, Alejandro Soto-Gutierrez, José G. Pichel, Darlene E. Berryman, Dirk Mayer, , Sui Seng Tee
This study identifies GH/IGF-1 signaling as a regulator of KHK expression, limiting fructose metabolism in the liver and contributing to MASLD.
bioRxiv · Jan 1, 2025 · PreprintMolecular Biology