Sui Seng Tee

Cirrhosis severity modulates proteomic and immune landscapes in hepatocellular carcinoma

This study identifies proteomic and immune changes in hepatocellular carcinoma linked to cirrhosis severity, revealing a continuum of biological remodeling rather than discrete molecular states.

The impact of high-fat and obesogenic diets on brain volume in a commercially available mouse model of fatty liver disease

This study examines the effects of high-fat and obesogenic diets on brain volume in a mouse model of fatty liver disease, finding significant changes in specific brain regions.

Sweet science: Exploring the impact of fructose and glucose on brown adipocyte differentiation using optical diffraction tomography

This study shows that fructose impairs brown adipocyte differentiation and function in both mice and humans, affecting lipid droplet formation and adipogenic gene expression.

Hepatic fructose metabolism is antagonized by growth hormone/insulin-like growth factor signaling via regulation of ketohexokinase expression

This study identifies GH/IGF-1 signaling as a regulator of KHK expression, limiting fructose metabolism in the liver and contributing to MASLD.

Establishing immortalized brown and white preadipocyte cell lines from young and aged mice

This paper establishes protocols for creating immortalized brown and white preadipocyte cell lines from young and aged mice to enable long-term studies of adipogenesis and adipocyte biology.

Fructose vs. Glucose: Modulating Stem Cell Growth and Function Through Sugar Supplementation

This study investigates how glucose and fructose, along with oxygen levels, affect stem cell growth, cytokine production, and differentiation in multicellular organisms.