Author

Alejandro Soto-Gutierrez

University of Pittsburgh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Bioinformatics· 1 Molecular Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:graph neural network· 1 Research Focus:imputation· 1

Frequent Co-Authors

Lanuza A. P. FaccioliiD· 3 shared Rodrigo M. Florentino· 2 shared Yiyue Sun· 2 shared Alina Ostrowska· 1 shared Bo Yang· 1 shared Brittany CodyiD· 1 shared Darlene E. BerrymaniD· 1 shared Dirk MayeriD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBioinformatics

Lanuza A. P. FaccioliORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

DGAT: A Dual-Graph Attention Network for Inferring Spatial Protein Landscapes from Transcriptomics

Haoyu Wang, Brittany Cody, Manuel Saavedra, Lanuza A. P. Faccioli, Rodrigo M. Florentino, Alejandro Soto-Gutierrez, Hatice Ulku Osmanbeyoglu

DGAT imputes spatial protein expression from transcriptomics-only data, revealing cell states and tissue organization not visible from RNA alone.

Nature Communications · May 21, 2026Peer-reviewedBioinformatics

Hepatic fructose metabolism is antagonized by growth hormone/insulin-like growth factor signaling via regulation of ketohexokinase expression

Salaheldeen Elsaid, Prathibha Meesala, Youngshim Choi, Liqing Yu, Yang Xiao, Mitchell A. Lazar, Patricia Pérez‐Matute, Edward Owen List, Lanuza A.P. Faccioli, Yiyue Sun, Rodrigo Machado Florentino, Alejandro Soto-Gutierrez, José G. Pichel, Darlene E. Berryman, Dirk Mayer, , Sui Seng Tee

This study identifies GH/IGF-1 signaling as a regulator of KHK expression, limiting fructose metabolism in the liver and contributing to MASLD.

bioRxiv · Jan 1, 2025 · PreprintMolecular Biology

A rat model of cirrhosis with well-differentiated hepatocellular carcinoma induced by thioacetamide

Zhiping Hu, Takeshi Kurihara, Yiyue Sun, Zeliha Cetin, Rodrigo M. Florentino, Lanuza A. P. Faccioli, Zhenghao Liu, Bo Yang, Alina Ostrowska, Joseph D. Locker, Alejandro Soto-Gutierrez, Evan R. Delgado

This study develops a rat model of cirrhosis-induced hepatocellular carcinoma using thioacetamide, showing fibrosis, altered liver architecture, and increased AFP levels.

bioRxiv · Apr 18, 2024Pathology