Antibody Blockade of Ly49/MHC-I interactions enhances Innate and Adaptive Immunity Against Cancer Metastasis
Abir Kumar Panda, Surajit Sinha, Kannan Natarajan, Jiansheng Jiang, Sruthi Chempati, Soha Kazmi, Yong-hee Kim, Suveena Sharma, Paul Schaughency, Lisa F. Boyd, Jonathan Matthew Hernandez, David H. Margulies, Ethan M. Shevach
This study shows that the anti-MHC-I antibody M1/42 enhances anti-tumor immunity by activating NK and adaptive immune cells, reducing metastasis in mouse models of cancer.
bioRxiv · May 12, 2026 · PreprintCancer Biology