Author

David H. Margulies

National Institutes of HealthORCID 0000-0001-8530-7375Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:host-pathogen & immune response· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Jiansheng JiangiD· 2 shared Kannan NatarajaniD· 2 shared Lisa F. BoydiD· 2 shared Abir Kumar PandaiD· 1 shared Allison B. LupatkiniD· 1 shared Ethan M. ShevachiD· 1 shared Jonathan Matthew HernandeziD· 1 shared Paul SchaughencyiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersImmunology

Jiansheng JiangORCID

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2 papers

Recent·Most cited

Cryo-EM and X-ray structures of an anti-MHC-I monoclonal antibody/H2-Kb complex reveal the basis of conformational dependence and allelic specificity

Jiansheng Jiang, Kannan Natarajan, Reanne Towler, Lisa F. Boyd, Allison B. Lupatkin, Rick K Huang, David H. Margulies

The paper reports cryo-EM and X-ray structures of an anti-MHC-I mAb/H2-Kb complex, revealing conformational epitope details and allelic specificity.

bioRxiv · Sep 16, 2026 · PreprintImmunology

Antibody Blockade of Ly49/MHC-I interactions enhances Innate and Adaptive Immunity Against Cancer Metastasis

Abir Kumar Panda, Surajit Sinha, Kannan Natarajan, Jiansheng Jiang, Sruthi Chempati, Soha Kazmi, Yong-hee Kim, Suveena Sharma, Paul Schaughency, Lisa F. Boyd, Jonathan Matthew Hernandez, David H. Margulies, Ethan M. Shevach

This study shows that the anti-MHC-I antibody M1/42 enhances anti-tumor immunity by activating NK and adaptive immune cells, reducing metastasis in mouse models of cancer.

bioRxiv · May 12, 2026 · PreprintCancer Biology