This study shows that the anti-MHC-I antibody M1/42 enhances anti-tumor immunity by activating NK and adaptive immune cells, reducing metastasis in mouse models of cancer.

bioRxiv · May 12, 2026 · PreprintCancer Biology

PI3Kdelta promotes T cell effector differentiation and plasticity during chronic infection

Andrea Pichler, Jennifer Leigh Cannons, Dominic P. Golec, Julie M. Reilley, Dan Corral, Eduard Ansaldo, Qin Xu, Subrata Paul, Paul Schaughency, Francisco A. Otaizo-Carrasquero, Stacie M. Anderson, Anshu Deewan, Dorian B. McGavern, Pamela L. Schwartzberg

This study shows that activated PI3Kdelta reduces TCF-1+ stem-like CD8+ T cells but promotes effector differentiation and viral control during chronic infection.

bioRxiv · Dec 23, 2025 · PreprintImmunology

Not1 and Not4 inversely determine mRNA solubility that sets the dynamics of co-translational events

George Edward Allen, Benjamin Weiss, Olesya O. Panasenko, Susanne Huch, Zoltán Villányi, Benjamin Albert, Daniel Dilg, Marina Zagatti, Paul Schaughency, Susan E. Liao, J L Corden, Christine Polte, David Shore, Zoya Ignatova, Vicent Pelechano, Martine A. Collart

The paper shows that Not1 and Not4 oppositely regulate mRNA solubility, affecting co-translational dynamics in yeast.

Genome biology · Feb 20, 2023Peer-reviewedMolecular Biology