Phase separation behavior of TDP-43 governs its protein interactome and regulation of alternative splicing
Yelyzaveta Zadorozhna, Federico Uliana, Emanuele Zippo, Anke Busch, Niklas Kretschmer, Simone Mosna, Yongwon Suk, Jiaxuan Chen, Martina Hallegger, Carla Schmidt, Lukas S. Stelzl, Dorothee Dormann
This study investigates how TDP-43 phase separation affects its protein interactome and regulation of alternative splicing, showing PS-dependent interactions with RNA regulators.
bioRxiv · Aug 28, 2026 · PreprintBiochemistry