Emanuele Zippo

This study shows that kinase-phosphatase cycles drive self-sustained oscillations in TDP-43 condensates through differential recruitment and slow redistribution of enzymes.

This study investigates how TDP-43 phase separation affects its protein interactome and regulation of alternative splicing, showing PS-dependent interactions with RNA regulators.

The paper uses molecular simulations to study how phosphorylation by CK1δ affects TDP-43 condensates and aggregation, finding that phosphorylation patterns depend on sequence and charge rather than position.