Targeting the host factor HGS-viral membrane protein interaction in coronavirus infection
Xubing Long, Rongrong Chen, Rong Bai, Buyun Tian, Yu Cao, K Chen, Fu‐Yu Li, Yiliang Wang, Yongjie Tang, Qi Yang, Liping Ma, Fan Wang, Maoge Zhou, Xianjie Qiu, Yongzhi Lu, , Zonghong Li
This study identifies HGS as a host factor critical for coronavirus infection and discovers RTB as a broad-spectrum antiviral by disrupting HGS-M protein interaction.
Journal of Clinical Investigation · Dec 16, 2025Peer-reviewedMicrobiology