GeneticsbioRxivPreprint
A Cas9-fusion proximity-based approach generates an Irak1-Mecp2 tandem duplication mouse model for the study of MeCP2 duplication syndrome.
Eleonora Maino, Ori Scott, Samar Z. Rizvi…·Evgueni A. Ivakine
This paper describes a CRISPR/Cas9-based method to create a mouse model with a tandem duplication of Irak1 and Mecp2, which exhibits MDS-like neurological and immune phenotypes.
DOI 10.1101/2023.02.07.527511