Janet Rossant

The paper develops a comprehensive reference tool for human embryogenesis using integrated single-cell RNA-sequencing data to benchmark embryo models.

The paper shows that fibronectin-dependent tissue stiffness controls durotaxis and cell rearrangements through a phase transition model in mouse limb bud mesoderm.

This paper describes a CRISPR/Cas9-based method to create a mouse model with a tandem duplication of Irak1 and Mecp2, which exhibits MDS-like neurological and immune phenotypes.

This study examines FGFR2 dynamics in mouse embryos, showing its correlation with PE cells increases during blastocyst development, supporting FGF's role in maintaining rather than initiating the PE lineage.

This paper develops CRISPR-engineered mouse lines for rapid and specific degradation of endogenous proteins in vivo, revealing stage-specific requirements for condensin complexes in lymphocyte division.

This paper develops a Nutm1 knock-in reporter mouse model to visualize post-meiotic spermatids and monitor spermiogenesis in live mice.

This study develops a YAP fusion reporter mouse line and uses live imaging to analyze YAP localization dynamics during mouse embryonic development.

The paper demonstrates that extracellular vesicles from amniotic fluid stem cells can rescue impaired fetal lung development in experimental models.

The paper introduces 2C-HR-CRISPR, a method for efficiently generating targeted large insertions in mouse embryos, and demonstrates its use in creating fluorescent reporter mouse lines and assessing protein function.

The paper develops a computational model using Boolean logic to predict pluripotent stem cell fate transitions in response to signaling inputs.

This study shows that Baf60c regulates gene expression programs critical for heart development and function by interacting with Myocardin and controlling contractile proteins and metabolic genes.