Author

Ameet S. Sengar

Hospital for Sick ChildrenORCID 0000-0002-6328-1108Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 4 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 5 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2

Frequent Co-Authors

Michael W. SalteriD· 5 shared Hongbin LiiD· 3 shared Adam D. Marc· 1 shared Alana Iaboni· 1 shared Alea A. MillsiD· 1 shared Alessandro GozziiD· 1 shared Alex P. A. DonovaniD· 1 shared Alex S. NordiD· 1 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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5 shared papersNeuroscience

Michael W. SalterORCID

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Author profile →

5 papers

Recent·Most cited

Assigning Targetable Pathways to Transdiagnostic Subgroups Across Neurodevelopmental Disorders

Jacob Ellegood, Antoine Beauchamp, Yohan Yee, Gabe Devenyi, Justine Ziolkowski, Lily R. Qiu, Rand Askalan, Muhammad Ayub, Philipp Suetterlin, Alex P. A. Donovan, M. Albert Basson, Katherine Quesnel, Nathalie G. Bérubé, Taeseon Woo, David Quentin Beversdorf, , Jill L. Silverman

The paper identifies molecular pathways associated with neurodevelopmental disorder subgroups using neuroimaging data from mice and humans.

bioRxiv · Mar 4, 2025 · PreprintNeuroscience

Blocking Src-PSD-95 interaction rescues glutamatergic signaling dysregulation in schizophrenia.

Robert E. Featherstone, Hongbin Li, Ameet S. Sengar, Karin E. Borgmann‐Winter, Olya Melnychenko, Lindsey M. Crown, Raymond L. Gifford, Felix Amirfathi, Anamika Banerjee, Krishna Parekh, Margaret Heller, Wenyu Zhang, Adam D. Marc, Michael W. Salter, Steven J. Siegel, Chang-Gyu Hahn

This study shows that blocking the Src-PSD-95 interaction with a peptide rescues NMDAR hypofunction and improves behavioral deficits in schizophrenia models.

bioRxiv · Mar 8, 2024 · PreprintNeuroscience

Conserved transcriptional programming across sex and species after peripheral nerve injury predicts treatments for neuropathic pain

Shahrzad Ghazisaeidi, Milind M. Muley, YuShan Tu, David P. Finn, Mahshad Kolahdouzan, Graham M. Pitcher, Doyeon Kim, Ameet S. Sengar, Arun K Ramani, Michael Brudno, Michael W. Salter

The paper identifies conserved transcriptional changes across sex and species after peripheral nerve injury and predicts a new analgesic treatment using a drug-gene interactome analysis.

British Journal of Pharmacology · Jun 19, 2023Peer-reviewedNeuroscience

A Cas9-fusion proximity-based approach generates an Irak1-Mecp2 tandem duplication mouse model for the study of MeCP2 duplication syndrome.

Eleonora Maino, Ori Scott, Samar Z. Rizvi, Shagana Visuvanathan, Youssif Ben Zablah, Hongbin Li, Ameet S. Sengar, Michael W. Salter, Zhengping Jia, Janet Rossant, Ronald D. Cohn, Bin Gu, Evgueni A. Ivakine

This paper describes a CRISPR/Cas9-based method to create a mouse model with a tandem duplication of Irak1 and Mecp2, which exhibits MDS-like neurological and immune phenotypes.

bioRxiv · Feb 7, 2023 · PreprintGenetics

Alternative splicing of GluN1 gates glycine-primed internalization of NMDA receptors

Hongbin Li, Vishaal Rajani, Lu Han, Danielle Chung, James E. Cooke, Ameet S. Sengar, Michael W. Salter

This study shows that alternative splicing of the GluN1 subunit affects glycine priming of NMDA receptors, influencing their internalization and synaptic dynamics.

bioRxiv · Dec 18, 2020 · PreprintNeuroscience