Michael W. Salter

TRACR is a transneuronal tracing system that uses synthetic Notch technology to label postsynaptic neurons and analyze circuit connectivity in the mouse visual system.

This study shows that CD206+ meningeal macrophages mask mechanical hypersensitivity in male rats after skin incision but not in females.

This paper identifies that N1 cassette-lacking NMDA receptors mediate ketamine's antidepressant effect by remaining blocked during neuronal firing.

The paper identifies molecular pathways associated with neurodevelopmental disorder subgroups using neuroimaging data from mice and humans.

The paper identifies calcium-driven lipid scrambling as the mechanism activating NINJ1-mediated plasma membrane rupture during lytic cell death.

This study shows that Beclin 1 inhibition exacerbates pain hypersensitivity in male mice but not females, suggesting sex-specific therapeutic targets for pain management.

This study shows that blocking the Src-PSD-95 interaction with a peptide rescues NMDAR hypofunction and improves behavioral deficits in schizophrenia models.

This study identifies hyperexcitable network events called reverberating super bursts in MECP2 null neuronal networks and shows they can be mitigated by a calcium chelator.

The paper investigates synapse-specific diversity of GluN2 subunits in spinal lamina I neurons and shows how they differentially tune depolarization events.

The paper identifies conserved transcriptional changes across sex and species after peripheral nerve injury and predicts a new analgesic treatment using a drug-gene interactome analysis.

This paper describes a CRISPR/Cas9-based method to create a mouse model with a tandem duplication of Irak1 and Mecp2, which exhibits MDS-like neurological and immune phenotypes.

This study shows that Orai1 channels regulate microglial reactivity and neuropathic pain, with sexual dimorphism observed in their effects.

This study examines the effects of MECP2 mutations on neuronal and network phenotypes in human stem cell-derived excitatory neurons, showing a spectrum of morphological, electrophysiological, and circuitry changes based on mutation severity.

This study shows that alternative splicing of the GluN1 subunit affects glycine priming of NMDA receptors, influencing their internalization and synaptic dynamics.

This study uses single-cell RNA sequencing to analyze spinal cord microglia responses to nerve injury, identifying sex- and time-specific changes and a role for ApoE in neuropathic pain.