Improved Tumor Blood Flow Enhances the Abscopal Effect: Preclinical Assessment in Mice Treated with Combined Radiation and PD-1 Blockade Therapy
Kota Yamashita, Jeffrey Brender, Yu Saida, Yasunori Otowa, Horie Kazumasa, Takeshi Ito, Kazutoshi Yamamoto, Helmut Merkle, William Marston Linehan, Murali Cherukuri Krishna, Shun Kishimoto
This study shows that improving tumor blood flow enhances the abscopal effect in mice treated with radiation and PD-1 blockade, by increasing immune activation and reducing hypoxia.
bioRxiv · May 4, 2025 · PreprintCancer Biology