Kazutoshi Yamamoto

This paper introduces SPIR-PRESS, a magnetic resonance spectroscopy method that improves lactate detection in brain tumors by reducing lipid interference, showing increased sensitivity and broader metabolite profiling.

This study shows that improving tumor blood flow enhances the abscopal effect in mice treated with radiation and PD-1 blockade, by increasing immune activation and reducing hypoxia.

This study uses EPR oximetry to assess kidney oxygen levels in mice with kidney injury, showing increased pO2 post-injury and high-resolution spatial mapping of oxygen distribution.

This study shows that pharmacological ascorbate induces transient hypoxia in pancreatic ductal adenocarcinoma, enhancing the efficacy of the hypoxia-activated prodrug evofosfamide in some tumor models.

This study investigates metabolic and imaging phenotypes in prostate cancer linked to RB1 and TP53 loss, finding metabolic changes that may inform multimodal imaging strategies.