Jeffrey Brender

This paper introduces SPIR-PRESS, a magnetic resonance spectroscopy method that improves lactate detection in brain tumors by reducing lipid interference, showing increased sensitivity and broader metabolite profiling.

The paper predicts destabilizing tyrosine phosphorylations in cancers using machine learning, finding 58% of recurrent phosphorylations are destabilizing and identifying pathway and network patterns associated with these events.

This study shows that improving tumor blood flow enhances the abscopal effect in mice treated with radiation and PD-1 blockade, by increasing immune activation and reducing hypoxia.

This study uses EPR oximetry to assess kidney oxygen levels in mice with kidney injury, showing increased pO2 post-injury and high-resolution spatial mapping of oxygen distribution.

This study shows that pharmacological ascorbate induces transient hypoxia in pancreatic ductal adenocarcinoma, enhancing the efficacy of the hypoxia-activated prodrug evofosfamide in some tumor models.

The paper distinguishes closely related pancreatic cancer subtypes in vivo using 13C glucose MRI without hyperpolarization by detecting metabolic differences through tensor decomposition.

This paper introduces a method to image glucose metabolism using 13C-MRS with tensor decomposition to enhance signal-to-noise ratio, enabling non-hyperpolarized imaging of the Warburg effect with high temporal and spatial resolution.