Lipid Flippase Mediated Membrane Asymmetry Governs Extracellular Vesicles Biogenesis and Host Interactions in Cryptococcus neoformans
Siddhi Pawar, Yu Zhnag, Christopher Varsanyi, Varsha Gadiyar, Samantha L. Avina, Raymond B. Birge, Chaoyang Xue
This study shows that Cdc50, a lipid flippase regulatory subunit in Cryptococcus neoformans, controls membrane lipid homeostasis, extracellular vesicle biogenesis, and macrophage interactions, with loss of Cdc50 increasing phagocytosis and susceptibility to macrophage killing.
bioRxiv · Jun 13, 2026 · PreprintMicrobiology