Varsha Gadiyar

Cardiomyocyte-derived Wnt5a drives doxorubicin-induced cardiomyopathy by amplifying cellular senescence

This study identifies Wnt5a as a driver of doxorubicin-induced cardiomyopathy by amplifying cellular senescence through a Wnt5a-Fzd2 feed-forward axis.

Lipid Flippase Mediated Membrane Asymmetry Governs Extracellular Vesicles Biogenesis and Host Interactions in Cryptococcus neoformans

This study shows that Cdc50, a lipid flippase regulatory subunit in Cryptococcus neoformans, controls membrane lipid homeostasis, extracellular vesicle biogenesis, and macrophage interactions, with loss of Cdc50 increasing phagocytosis and susceptibility to macrophage killing.

Phospholipid Scramblases TMEM16F and Xkr8 regulate distinct features of Phosphatidylserine (PS) externalization and immune regulation in the tumor microenvironment to regulate tumor growth

This study shows that Xkr8 and TMEM16F regulate distinct PS externalization mechanisms in the tumor microenvironment, influencing immune evasion and tumor growth.

Phosphatidylserine (PS)-targeting chimeric Interferon (IFN) fusion proteins for anti-tumor applications

This paper develops PS-targeting chimeric IFN fusion proteins that enhance anti-tumor activities by combining IFN-β and IFN-λ with the PS-binding Gas6 domain.