Sleeping Beauty mutagenesis identifies BACH2 and other regulators of CD8+T cell exhaustion, persistence in vivo, and CAR-T function under tumor-associated chronic antigen stimulation
Chang-Jung Lee, Alex T. Larsson, Tyler A. Jubenville, Wendy A. Hudson, Zachary J. Seeman, Carli M. Stewart, Alexander K. Tsai, Adam L. Burrack, Brooke L. Kimball, Elizabeth L. Siegler, Vianca V. Vianzon, Erin E. Nolan, Yu-Ling Yang, Christopher M. Stehn, Daryl M. Gohl, , David A. Largaespada
The paper uses Sleeping Beauty mutagenesis to identify BACH2 and other genes that enhance CD8+ T cell persistence and function under chronic antigen stimulation, improving engineered T cell therapies.
Journal for ImmunoTherapy of Cancer · Jul 1, 2026Peer-reviewedImmunology