Author
University of MinnesotaORCID 0000-0003-0285-3624Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Meghna Saxena, Love Li, Brady G. Strittmatter…·Robert Thomas Galvin
This study develops a gene-enhanced HSV therapy for MPNST by exploiting PRC2 loss and tumor-regulated ICP34.5 expression to improve viral efficacy.
Ritu C. Shah, Alex T. Larsson, Belinda B. Garana…·Sara J.C. Gosline
The paper develops EXACT, a framework combining ex vivo drug screening with transcriptomic analysis to identify effective drug combinations for rare cancers, finding a MEK and HDAC inhibitor combination shows enhanced activity.
Chang-Jung Lee, Alex T. Larsson, Tyler A. Jubenville…·David A. Largaespada
The paper uses Sleeping Beauty mutagenesis to identify BACH2 and other genes that enhance CD8+ T cell persistence and function under chronic antigen stimulation, improving engineered T cell therapies.
Christopher M. Stehn, Liangjun Wang, Davis M. Seelig…·David A. Largaespada
This study identifies cell surface proteome changes in MPNSTs due to PRC2 loss, revealing PTK7 as a promising therapeutic target using antibody-drug conjugates.