Author

Christopher M. Stehn

University of MinnesotaORCID 0000-0003-2911-1954Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

David A. LargaespadaiD· 3 shared Zachary J. SeemaniD· 3 shared Alex T. LarssoniD· 2 shared Chang-Jung LeeiD· 2 shared Adam J. DupuyiD· 1 shared Adam L. BurrackiD· 1 shared Alanna Halloran· 1 shared Alexander K. TsaiiD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersCancer Biology

David A. LargaespadaORCID

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintOct 14, 2026

Biomarker-driven and gene-enhanced viral therapy for malignant peripheral nerve sheath tumor

Meghna Saxena, Love Li, Brady G. Strittmatter…·Robert Thomas Galvin

This study develops a gene-enhanced HSV therapy for MPNST by exploiting PRC2 loss and tumor-regulated ICP34.5 expression to improve viral efficacy.

DOI 10.64898/2026.10.12.758653

mouseexperimental assay

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ImmunologyJournal for ImmunoTherapy of CancerPeer-reviewedJul 1, 2026

Sleeping Beauty mutagenesis identifies BACH2 and other regulators of CD8+T cell exhaustion, persistence in vivo, and CAR-T function under tumor-associated chronic antigen stimulation

Chang-Jung Lee, Alex T. Larsson, Tyler A. Jubenville…·David A. Largaespada

The paper uses Sleeping Beauty mutagenesis to identify BACH2 and other genes that enhance CD8+ T cell persistence and function under chronic antigen stimulation, improving engineered T cell therapies.

1 citation

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Cancer BiologyNeuro-Oncology AdvancesPeer-reviewedJan 1, 2026

The Cell Surface Proteome of Malignant Peripheral Nerve Sheath Tumors Reveals Therapeutic Targets

Christopher M. Stehn, Liangjun Wang, Davis M. Seelig…·David A. Largaespada

This study identifies cell surface proteome changes in MPNSTs due to PRC2 loss, revealing PTK7 as a promising therapeutic target using antibody-drug conjugates.

DOI 10.1093/noajnl/vdag189

humanproteomics

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