Author

Alexander K. Tsai

University of MinnesotaORCID 0000-0002-4014-1946Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Assay:proteomics· 1

Frequent Co-Authors

Adam L. BurrackiD· 2 shared Ingunn M. StromnesiD· 2 shared Adam J. DupuyiD· 1 shared Alex T. LarssoniD· 1 shared Ayaka Hulbert· 1 shared Branden S. MoriarityiD· 1 shared Brooke L. KimballiD· 1 shared Carli M. StewartiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersImmunology

Adam L. BurrackORCID

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Author profile →

2 papers

Recent·Most cited

Abrogating TGFβ signaling in TCR-engineered T cells and enhancing antigen processing by tumor cells promotes sustained therapeutic activity in pancreatic ductal adenocarcinoma

Alexander K. Tsai, Meagan R. Rollins, Madeline A. Ellefson, Zoe C. Schmiechen, Adam L. Burrack, Ayaka Hulbert, Guhan Qian, Hongrong Zhang, Eduardo Cruz-Hinojoza, Jonah Z. Butler, Jason S. Mitchell, Olivia C. Ghirardelli Smith, Stephen D. O’Flanagan, Jenny Krause, Grant H. Hickok, , Ingunn M. Stromnes

This study shows that blocking TGFβ signaling in TCR-engineered T cells and enhancing antigen processing in tumor cells improves their therapeutic effectiveness against pancreatic ductal adenocarcinoma.

Journal for ImmunoTherapy of Cancer · Oct 1, 2026Peer-reviewedImmunology

Sleeping Beauty mutagenesis identifies BACH2 and other regulators of CD8+T cell exhaustion, persistence in vivo, and CAR-T function under tumor-associated chronic antigen stimulation

Chang-Jung Lee, Alex T. Larsson, Tyler A. Jubenville, Wendy A. Hudson, Zachary J. Seeman, Carli M. Stewart, Alexander K. Tsai, Adam L. Burrack, Brooke L. Kimball, Elizabeth L. Siegler, Vianca V. Vianzon, Erin E. Nolan, Yu-Ling Yang, Christopher M. Stehn, Daryl M. Gohl, , David A. Largaespada

The paper uses Sleeping Beauty mutagenesis to identify BACH2 and other genes that enhance CD8+ T cell persistence and function under chronic antigen stimulation, improving engineered T cell therapies.

Journal for ImmunoTherapy of Cancer · Jul 1, 2026Peer-reviewedImmunology