Deep sequencing of a large family of isogenic mice enables complex variants discovery and accurate phenotype mapping
Flavia Villani, Thomas A. Sasani, Mikhail Maksimov, Mustafa Hakan Gunturkun, Nichole Ma, Yu-yu Ren, Daphna Rothschild, Hao Chen, Lu Lu, Beth L. Dumont, Kelley Harris, Melissa Gymrek, Vincenza Colonna, Jonathan K. Pritchard, Abraham A Palmer, , David George Ashbrook
The paper uses linked-read whole-genome sequencing to identify DNA variants in BXD mice and maps them to phenotypes, enabling systems genetics and precision medicine.
bioRxiv · Apr 21, 2022 · PreprintGenomics