Steven L. Britton

Inborn cardiorespiratory fitness and exercise training modulate brown adipose tissue function and plasticity in early life

This study shows that early life exercise increases energy expenditure and BAT thermogenic capacity regardless of inborn fitness, while inborn fitness affects BAT proteome composition.

Skeletal muscle enhancer programming of intrinsic cardiorespiratory fitness

The paper identifies enhancer architecture differences in skeletal muscle between high and low cardiorespiratory fitness rats, linking them to gene expression and metabolic traits.

Shared and distinct adaptations to early-life exercise training based on inborn fitness

This study shows early-life exercise training can mitigate low inborn cardiorespiratory fitness effects, but molecular adaptations vary based on innate fitness.

Organ specificity and commonality of epigenetic aging in low- and high-running capacity rats

This study examines how cardiorespiratory fitness affects epigenetic aging in different organs of rats, finding organ-specific and common changes in DNA methylation.

Aerobic capacity and exercise mediate protection against hepatic steatosis via enhanced bile acid metabolism.

The paper shows aerobic capacity and exercise enhance bile acid metabolism, which is critical for reducing hepatic steatosis in mice.

Metformin treatment results in distinctive skeletal muscle mitochondrial remodeling in rats with different intrinsic aerobic capacities

This study shows metformin induces different mitochondrial remodeling in rat skeletal muscle based on baseline aerobic capacity and muscle type.

Interactive effects of aging and aerobic capacity on energy metabolism-related metabolites of serum, skeletal muscle, and white adipose tissue

The paper examines how aging and aerobic capacity interact to affect metabolites in serum, muscle, and adipose tissue in rats, showing distinct metabolic changes in different tissues.

High-density SNP array and genome sequencing reveal signatures of selection in a divergent selection rat model for aerobic running capacity

The paper identifies genomic regions under differential selection between two rat lines with divergent aerobic running capacity using SNP arrays and genome sequencing.