BDNF controls neuropsychiatric manifestation via autophagic regulation of p62 and GABAA receptor trafficking
Toshifumi Tomoda, Akiko Sumitomo, Rammohan Shukla, Yuki Hirota-Tsuyada, Hitoshi Miyachi, Hyunjung Oh, Leon French, Etienne Sibille
This study shows that reduced BDNF leads to increased p62 and decreased GABAAR surface expression, contributing to behavioral deficits in mice, and suggests similar changes in human depression.
bioRxiv · Jan 11, 2019 · PreprintNeuroscience