Author

Etienne Sibille

Centre for Addiction and Mental HealthPrimary ORCID profile (0000-0001-5832-6570 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Etienne SibilleiD1 paper · University of Toronto

Biology Disciplines

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Neuroscience· 3 Genetic & Genomic Medicine· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Organism:mouse· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:gene regulatory network inference· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Mounira BanasriD· 2 shared Thomas D. PrévotiD· 2 shared Toshifumi TomodaiD· 2 shared Aaron Guan· 1 shared Akiko SumitomoiD· 1 shared Aleksandra Vidojevic· 1 shared Alexandre Guet-McCreightiD· 1 shared Ali Ezzeddine· 1 shared

Activity by Year

2018-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersNeuroscience

Mounira BanasrORCID

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5 papers

Recent·Most cited

Dual Roles of Interferon-γ Receptor in Somatostatin Interneurons at Baseline and During Inflammation

Sara Rezaei, Toshifumi Tomoda, Michael Marcotte, Thomas D. Prévot, Mounira Banasr, Yashika Bansal, Ali Ezzeddine, Aaron Guan, Erica Vieira, Etienne Sibille

This study investigates the role of IFN-γ receptor signaling in SST interneurons, showing it supports normal behavior and molecular homeostasis while mediating inflammation-induced deficits.

bioRxiv · Oct 13, 2026 · PreprintNeuroscience

Linking age changes in human cortical microcircuits to impaired brain function and EEG biomarkers

Alexandre Guet-McCreight, Shreejoy J. Tripathy, Etienne Sibille, Etay Hay

The paper links age-related cellular and synaptic changes in human cortical microcircuits to impaired brain function and EEG biomarkers using computational models and machine learning.

Aging Cell · Dec 14, 2025Peer-reviewedNeuroscience

Distinct Neurodevelopmental Signatures of Sex-Specific Transcriptome-Based Polygenic Risk Scores for Depression

Sarah S. Rashid, Kevan P. Clifford, Amy E. Miles, Fernanda C. Dos Santos, Etienne Sibille, Yuliya S. Nikolova

The paper develops sex-specific transcriptome-based polygenic risk scores for depression and evaluates their associations with brain structure and symptoms in adolescents.

medRxiv · Jul 31, 2025 · PreprintGenetic & Genomic Medicine

BDNF controls neuropsychiatric manifestation via autophagic regulation of p62 and GABAA receptor trafficking

Toshifumi Tomoda, Akiko Sumitomo, Rammohan Shukla, Yuki Hirota-Tsuyada, Hitoshi Miyachi, Hyunjung Oh, Leon French, Etienne Sibille

This study shows that reduced BDNF leads to increased p62 and decreased GABAAR surface expression, contributing to behavioral deficits in mice, and suggests similar changes in human depression.

bioRxiv · Jan 11, 2019 · PreprintNeuroscience

Potential combined pro-cognitive, anxiolytic and antidepressant properties of novel GABAA receptor positive modulators with preferential efficacy at the α5-subunit

Thomas D. Prevot, Guanguan Li, Aleksandra Vidojevic, Keith A. Misquitta, Corey Fee, Anja Santrac, Daniel E. Knutson, Michael R. Stephen, Revathi Kodali, Nicolas M. Zahn, Leggy A. Arnold, Petra Scholze, Janet L. Fisher, Bojan D. Marković, Mounira Banasr, , Etienne Sibille

This study identifies three novel GABAA receptor modulators that show anxiolytic, antidepressant, and pro-cognitive effects in mice, unlike diazepam.

bioRxiv · May 29, 2018 · PreprintPharmacology & Toxicology