Hypobaric hypoxia drives citrate cycle reprogramming to suppress tumor progression
Yixing Gao, Xiuju He, E Guoji, Yan Wang, Shirui Huang, Dan Cai, Yumei Deng, Ping Gan, Rui Feng, Qian Liang, Ziyi Tang, Gang Xu, Jian Chen, Hongyu Xue, Qiutong Wang, , Erlong Zhang
This study shows hypobaric hypoxia suppresses tumor progression by reprogramming the citrate cycle and inhibiting the HIF-1 pathway, enhancing antitumor immune response and improving therapy outcomes.
bioRxiv · Aug 15, 2025 · PreprintCancer Biology