A Novel 'Three-in-one' Mucosal Vaccine Elicits Broad Protection against Three Distinct Clusters of ACE2-using Sarbecoviruseses
Lin Liu, Haofeng Lin, Min Li, Xian Li, Shasha Wang, Mengxin Xu, Shuning Liu, Yunqi Hu, Meiqin Liu, Zhixiang Huang, Zhen Zhang, Ke Lan, Yu Zheng Chen, Huimin Yan, Li Zhou, , Qingguo Wu
This paper develops a three-in-one mucosal vaccine, 3Rs-NC, that elicits broad neutralizing antibodies against three ACE2-using sarbecovirus clusters and provides durable protection in mice.
bioRxiv · Jun 26, 2025 · PreprintImmunology