Ke Lan

The paper assesses neutralizing antibody responses to multiple coronaviruses in Wuhan population samples before and after the pandemic, finding enhanced cross-neutralizing activity against sarbecoviruses.

This study identifies PABPC1 as a host factor that selectively targets viral RNA with short poly(A) tails, leading to degradation and antiviral defense, and develops a synthetic therapeutic based on this mechanism.

This paper develops a three-in-one mucosal vaccine, 3Rs-NC, that elicits broad neutralizing antibodies against three ACE2-using sarbecovirus clusters and provides durable protection in mice.

The paper introduces RiboCalc, a model that quantitatively predicts transcript coding ability in human cells, revealing context-dependent coding transcripts.