Dual Pathways of Extracellular ATP Action in Cancer Cells: Purinergic Signaling Driven Senescence and Macropinocytic ATP Internalization
Nicole Stone, Ryan A. Ward, Lindsey M. Bachmann, Subhodip Adhicary, Corinne M. Nielsen, Nikunj Mehta, Yunsheng Li, Haiyun Zhang, Jingwen Song, Sam Prinz, Stephen Chang, Dennis A. Roberts, Stephen C. Bergmeier, Pratik Shriwas, Xiaozhuo Chen
This study identifies two pathways by which extracellular ATP affects cancer cells: macropinocytic uptake increasing intracellular ATP and purinergic receptor signaling inducing senescence.
European Journal of Cell Biology · Oct 1, 2026Peer-reviewedCancer Biology