Lindsey M. Bachmann

Dual Pathways of Extracellular ATP Action in Cancer Cells: Purinergic Signaling Driven Senescence and Macropinocytic ATP Internalization

This study identifies two pathways by which extracellular ATP affects cancer cells: macropinocytic uptake increasing intracellular ATP and purinergic receptor signaling inducing senescence.

A novel pan class-I glucose transporter inhibitor DRB18 exhibits synergistic effects in vitro and in vivo with paclitaxel against human non-small cell lung cancer

This study shows that DRB18, a pan-class I GLUT inhibitor, synergizes with paclitaxel to reduce NSCLC cell proliferation in vitro and tumor growth in vivo.