Cystatin C loaded in brain-derived extracellular vesicles rescues synapses after ischemic insult in vitro and in vivo
Yuqi Gui, Yohan Kim, Santra Brenna, Maximilian Wilmes, Giorgio Zaghen, Lennart Kuchenbecker-Pöls, Hannah Voß, Antonia Gocke, Hartmut Schlüter, Michaela Schweizer, Hermann C. Altmeppen, Tim Ullrich Magnus, Efrat Levy, Berta Puig
This study identifies cystatin C as a neuroprotective protein upregulated after stroke and shows that delivering it via brain-derived extracellular vesicles improves synaptic preservation in vitro and in vivo.
bioRxiv · Jun 16, 2023 · PreprintNeuroscience