Malik Alawi

CD73-derived adenosine at the blood-brain barrier confers protection in a mouse model of ischemic stroke

This study shows that enhancing CD73 in mouse brain endothelial cells reduces infarct volume and mortality after stroke by promoting adenosine production and modulating neuroinflammation.

Polyethylene terephthalate (PET) primary degradation products affect c-di-GMP-, cAMP-signaling and quorum sensing (QS) in Vibrio gazogenes DSM 21264

This study shows that PET degradation products BHET and TPA affect signaling pathways in Vibrio gazogenes, impacting biofilm formation and colony morphology.

Multiplexed mRNA analysis of brain-derived extracellular vesicles upon experimental stroke in mice reveals increased mRNA content related to inflammation and recovery processes

High-resolution analysis of Merkel Cell Polyomavirus in Merkel Cell Carcinoma reveals distinct integration patterns and suggests NHEJ and MMBIR as underlying mechanisms

This study identifies two MCPyV integration patterns in MCC and links them to NHEJ and MMBIR mechanisms, showing integration preference for open chromatin and viral promoter-driven oncogene expression.

Spatial Genome Organization as a Framework for Somatic Alterations in Human Cancer

The paper examines how somatic structural variations affect TAD boundaries and gene regulation in human cancers using whole genome sequencing data.

Germline determinants of the somatic mutation landscape in 2,642 cancer genomes

This study identifies germline genetic variants influencing somatic mutation patterns in 2,642 cancer genomes across 39 cancer types.

Comprehensive Molecular Characterization of Mitochondrial Genomes in Human Cancers

This study characterizes mitochondrial genomes in 2,700 cancer patients across 37 types using whole-genome sequencing and RNA-seq, revealing mutational patterns, truncating mutations, and nuclear transfer of mitochondrial DNA.

Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing

This study analyzes chromothripsis in 2,658 cancers using whole-genome sequencing, finding it prevalent across multiple cancer types with complex structural alterations.

Alternative interaction sites in the influenza A virus nucleoprotein mediate viral escape from the importin-α7 mediated nuclear import pathway

The paper identifies mutations in the influenza A virus nucleoprotein that enable escape from importin-7 mediated nuclear import but reduce replicative fitness in human cells.