Key role of P230 in the hinge region on the IgG architecture and function
Yuuki Koseki, Yuki Yamaguchi, Michihiko Aoyama, Kentaro Hiraka, Minoru Tada, Atsuji Kodama, Akinobu Senoo, Akiko Ishii‐Watabe, Takayuki Uchihashi, Kazuyoshi Murata, Susumu Uchiyama, Koichi Kato, Saeko Yanaka, José M. M. Caaveiro
This study investigates the role of Pro230 in the hinge region of IgG by deleting it, revealing structural changes and functional effects on FcγRI-mediated activity.
Journal of Medicinal Chemistry · Jan 29, 2026Peer-reviewedBiophysics