Author

Yuki Yamaguchi

The University of OsakaORCID 0000-0001-7856-4031Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Organism:non-human primate· 1 Assay:protein sequence· 1 Assay:proteomics· 1

Frequent Co-Authors

Susumu UchiyamaiD· 2 shared Akiko Ishii‐WatabeiD· 1 shared Akinobu SenooiD· 1 shared Atsuji KodamaiD· 1 shared José M. M. CaaveiroiD· 1 shared Kazuyoshi MurataiD· 1 shared Keiji NogamiiD· 1 shared Kentaro HirakaiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersBiophysics

Susumu UchiyamaORCID

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2 papers

Recent·Most cited

BiophysicsJournal of Medicinal ChemistryPeer-reviewedJan 29, 2026

Key role of P230 in the hinge region on the IgG architecture and function

Yuuki Koseki, Yuki Yamaguchi, Michihiko Aoyama…·José M. M. Caaveiro

This study investigates the role of Pro230 in the hinge region of IgG by deleting it, revealing structural changes and functional effects on FcγRI-mediated activity.

1 citation

proteomicsexperimental assay

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BioengineeringBloodPeer-reviewedNov 7, 2025

Engineered coagulation factor VIII with enhanced secretion and coagulation potential for hemophilia A gene therapy

Yuji Kashiwakura, Yuto Nakajima, Kio Horinaka…·Tsukasa Ohmori

This paper develops engineered FVIII variants for hemophilia A gene therapy, showing improved secretion, coagulation activity, and efficacy at lower vector doses in mice and macaques.

3 citations

mousenon-human primate

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