Author

Saeko Yanaka

Kyushu UniversityORCID 0000-0002-3513-5701Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Akinobu SenooiD· 3 shared José M. M. CaaveiroiD· 3 shared Takayuki UchihashiiD· 2 shared Akiko Ishii‐WatabeiD· 1 shared Akitsu MasudaiD· 1 shared Atsuji KodamaiD· 1 shared Hirofumi KosugeiD· 1 shared Jae Man LeeiD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersBiophysics

Akinobu SenooORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Structural basis for the intestinal protocadherin-based intermicrovillar adhesion complex

Akinobu Senoo, Pablo Adrian Guillen-Poza, Karin Fujishima, Hirofumi Kosuge, Takamasa Doumoto, Keisuke Kasahara, Tomohito Tanihara, Yuya Yoshida, Saeko Yanaka, Makoto Nakakido, Satoru Nagatoishi, Katsumi Maenaka, Shigehiro Ohdo, Naoya Matsunaga, Rubén Hervás, , José M. M. Caaveiro

The paper determines the Cryo-EM structure of the intestinal IMAC complex, revealing its heterotetrameric composition and structural features that enable microvilli adhesion and resilience to shear stress.

bioRxiv · May 14, 2026 · PreprintBiophysics

Characterization of high affinity IgM and IgG monoclonal antibodies against norovirus variants GII.4 and GII.17

Jumpei Tagawa, Saeko Yanaka, Yuri Kato, Akitsu Masuda, Jae Man Lee, Akinobu Senoo, Kosuke Oyama, Takayuki Uchihashi, Motohiro Nishida, Takahiro Kusakabe, José M. M. Caaveiro

This study generates and characterizes monoclonal IgM and IgG antibodies against norovirus variants GII.4 and GII.17, revealing differences in binding mechanisms and affinity.

Protein Science · Mar 12, 2026Peer-reviewedBiochemistry

Key role of P230 in the hinge region on the IgG architecture and function

Yuuki Koseki, Yuki Yamaguchi, Michihiko Aoyama, Kentaro Hiraka, Minoru Tada, Atsuji Kodama, Akinobu Senoo, Akiko Ishii‐Watabe, Takayuki Uchihashi, Kazuyoshi Murata, Susumu Uchiyama, Koichi Kato, Saeko Yanaka, José M. M. Caaveiro

This study investigates the role of Pro230 in the hinge region of IgG by deleting it, revealing structural changes and functional effects on FcγRI-mediated activity.

Journal of Medicinal Chemistry · Jan 29, 2026Peer-reviewedBiophysics