PTP1B inhibition promotes microglial phagocytosis in Alzheimer's disease models by enhancing SYK signaling
Yuxin Cen, Steven R. Alves, Dongyan Song, Christy Felice, Jonathan B. Preall, Linda Van Aelst, Nicholas K. Tonks
This study shows that inhibiting PTP1B enhances microglial phagocytosis and reduces Aβ burden in AD models by boosting SYK signaling.
Proceedings of the National Academy of Sciences · Feb 2, 2026Peer-reviewedMolecular Biology