Author

Linda Van Aelst

Cold Spring Harbor LaboratoryORCID 0000-0002-0870-012XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Neuroscience· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Christy Felice· 2 shared Evdokia MichalopoulouiD· 2 shared Nicholas K. TonksiD· 2 shared Shanu GeorgeiD· 2 shared Ahmad S. AltitiiD· 1 shared Alma L. BurlingameiD· 1 shared Ankur GargiD· 1 shared Ava SanniD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersMolecular Biology

Christy Felice

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

PTP1B inhibition promotes microglial phagocytosis in Alzheimer's disease models by enhancing SYK signaling

Yuxin Cen, Steven R. Alves, Dongyan Song, Christy Felice, Jonathan B. Preall, Linda Van Aelst, Nicholas K. Tonks

This study shows that inhibiting PTP1B enhances microglial phagocytosis and reduces Aβ burden in AD models by boosting SYK signaling.

Proceedings of the National Academy of Sciences · Feb 2, 2026Peer-reviewedMolecular Biology

Novel small-molecule inhibitors of the protein kinase DYRK: Potential Therapeutic candidates in cancer

Prabhadevi Venkataramani, Elad Elkayam, Ankur Garg, Kai Fan Cheng, Ahmad S. Altiti, Mingzhu He, Khushabu Thakur, Evdokia Michalopoulou, Camila Gonzalez, Christy Felice, Linda Van Aelst, Darryl Pappin, Leemor Joshua‐Tor, Yousef Al-Abed, Nicholas K. Tonks

This study identifies two selective DYRK1A inhibitors, FC-2 and FC-3, which show antitumor effects in glioblastoma models.

bioRxiv · Nov 5, 2025 · PreprintCancer Biology

Macropinocytosis enables metabolic recycling of extracellular DNA in cancer cells

Wen‐Hsuan Yang, Olivia T. Stamatatos, Evdokia Michalopoulou, Ava Sann, Paolo Cifani, Linda Van Aelst, Justin R. Cross, Tse-Luen Wee, Michael J. Lukey

This study shows cancer cells use macropinocytosis to take up extracellular DNA, which is then degraded to supply nucleotides, and highlights SLC29A3 as a key mediator of this process.

bioRxiv · Oct 22, 2025 · PreprintCancer Biology

Restoring transient connectivity during development improves dysfunctions in fragile X mice

Dimitri Dumontier, Samuel A Liebman, Viet-Hang Le, Shanu George, Deasia Valdemar, Linda Van Aelst, Gabrielle Pouchelon

The paper shows restoring transient connectivity in SST neurons improves circuit maturation and behavior in fragile X mice.

bioRxiv · Sep 8, 2024 · PreprintNeuroscience

Antibody-directed extracellular proximity biotinylation reveals Contactin-1 regulates axo-axonic innervation of axon initial segments.

Yuki Ogawa, Brian C. Lim, Shanu George, Juan A. Osés-Prieto, Joshua M. Rasband, Yael Eshed‐Eisenbach, Hamdan Hamdan, Supna Nair, Francesco Boato, Elior Peles, Alma L. Burlingame, Linda Van Aelst, Matthew Neil Rasband

The paper identifies Contactin-1 as an AIS cell surface protein that regulates axo-axonic innervation by interacting with Neurofascin and NrCAM.

Nature Communications · Oct 26, 2023Peer-reviewedNeuroscience