Author

Christy Felice

Cold Spring Harbor Laboratory

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Organism:mouse· 2 Approach:statistical model· 1

Frequent Co-Authors

Nicholas K. TonksiD· 4 shared Linda Van AelstiD· 2 shared Ahmad S. AltitiiD· 1 shared Ankur GargiD· 1 shared Camila Gonzalez· 1 shared Christopher A. Bonham· 1 shared Darryl PappiniD· 1 shared David L. SpectoriD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersCancer Biology

Nicholas K. TonksORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

PTP1B supports survival and regulates CFL1 and HSP90a abundance in trastuzumab-resistant HER2-positive breast cancer.

Vinay Mandati, Maria C. Panepinto, Christy Felice, Sean Krivitsky, Suzanne Russo, Payal K. Naik, Raditya Utama, David L. Spector, Paolo Cifani, Nicholas K. Tonks

This study identifies PTP1B as a survival dependency in trastuzumab-resistant HER2-positive breast cancer, showing it regulates CFL1 and HSP90a abundance through dephosphorylation.

bioRxiv · Oct 28, 2026 · PreprintCancer Biology

Inhibition of protein tyrosine phosphatase PTP1B function ameliorates pathophysiological deficits in Rett Syndrome

Christopher A. Bonham, Christy Felice, Lisa N. Christensen, Nicholas K. Tonks

The paper validates PTP1B inhibition as a therapeutic strategy that alleviates multiple symptoms in a mouse model of Rett syndrome.

bioRxiv · Jun 8, 2026 · PreprintNeuroscience

PTP1B inhibition promotes microglial phagocytosis in Alzheimer's disease models by enhancing SYK signaling

Yuxin Cen, Steven R. Alves, Dongyan Song, Christy Felice, Jonathan B. Preall, Linda Van Aelst, Nicholas K. Tonks

This study shows that inhibiting PTP1B enhances microglial phagocytosis and reduces Aβ burden in AD models by boosting SYK signaling.

Proceedings of the National Academy of Sciences · Feb 2, 2026Peer-reviewedMolecular Biology

Novel small-molecule inhibitors of the protein kinase DYRK: Potential Therapeutic candidates in cancer

Prabhadevi Venkataramani, Elad Elkayam, Ankur Garg, Kai Fan Cheng, Ahmad S. Altiti, Mingzhu He, Khushabu Thakur, Evdokia Michalopoulou, Camila Gonzalez, Christy Felice, Linda Van Aelst, Darryl Pappin, Leemor Joshua‐Tor, Yousef Al-Abed, Nicholas K. Tonks

This study identifies two selective DYRK1A inhibitors, FC-2 and FC-3, which show antitumor effects in glioblastoma models.

bioRxiv · Nov 5, 2025 · PreprintCancer Biology