Nicholas K. Tonks

This study identifies PTP1B as a survival dependency in trastuzumab-resistant HER2-positive breast cancer, showing it regulates CFL1 and HSP90a abundance through dephosphorylation.

The paper validates PTP1B inhibition as a therapeutic strategy that alleviates multiple symptoms in a mouse model of Rett syndrome.

This study shows that Ganaxolone inhibits PTP1B, restores TRKB/BDNF signaling, and rescues cellular morphology in CDKL5-deficient cells.

This study identifies and validates CSH-4044, a small-molecule inhibitor from fermented wheat germ extract, as a specific inhibitor of PIM and DYRK kinases with potential therapeutic applications.

This study shows that inhibiting PTP1B enhances microglial phagocytosis and reduces Aβ burden in AD models by boosting SYK signaling.

This study identifies two selective DYRK1A inhibitors, FC-2 and FC-3, which show antitumor effects in glioblastoma models.

This study shows JSP1 is essential for neutrophil adhesion and vascular inflammation via integrin-SRC signaling in a mouse model of LPS-TNF-induced injury.