Benchmarking scRNA-seq Copy Number Inference: A Comprehensive Evaluation and Practitioner Guide
Hung-Ching Chang, Yuxin Shi, Haoyu Cheng, Jian Zou, Alexander Chih-Chieh Chang, Brent Thomas Schlegel, Wenjia Wang, Daniel D. Brown, Fangyuan Chen, Sarah Wang, Danyang Li, Ria Sai, Noelle Michel, Steffi Oesterreich, Adrian V. Lee, George C. Tseng
This study benchmarks 12 scRNA-seq CNV inference methods across 28 datasets, finding allele-aware tools perform better with high-quality allelic data, while expression-centric tools are reliable with raw data.
bioRxiv · Apr 15, 2026 · PreprintCancer Biology