Fangyuan Chen

Estrogen receptor-positive cell line xenograft models recapitulate metastatic dissemination and endocrine response of invasive lobular breast carcinoma

This study shows that ER-positive ILC xenograft models replicate metastatic patterns and endocrine response of human invasive lobular breast carcinoma.

A Single-Cell Peripheral Immune Atlas Spanning High-Risk Lesions to Invasive Breast Cancer in Black and White Women

The paper constructs a single-cell peripheral immune atlas for Black and White women across breast disease states, identifying race-associated immune differences linked to chronic inflammation and immune aging in Black patients.

Benchmarking scRNA-seq Copy Number Inference: A Comprehensive Evaluation and Practitioner Guide

This study benchmarks 12 scRNA-seq CNV inference methods across 28 datasets, finding allele-aware tools perform better with high-quality allelic data, while expression-centric tools are reliable with raw data.

Targeting RET in Brain Metastases from Estrogen Receptor Positive Breast Cancer

This study identifies RET as a druggable target in estrogen receptor-positive breast cancer brain metastases and shows that Pralsetinib inhibits RET-driven metastatic properties.

EstroGene2.0: A multi-omic database of response to estrogens, ER-modulators, and resistance to endocrine therapies in breast cancer

EstroGene2.0 is a multi-omic database that compiles data on estrogen receptor responses and resistance in breast cancer, revealing diverse transcriptomic changes and identifying key targets.