Dominant negative FADD/MORT1 inhibits the development of intestinal intraepithelial lymphocytes with a marked defect on CD8αα+TCRγδ+ T cells
X. Zhang, L. Huo, L. Song, Z. Hu, X. Wang, Y. Han, Y. Wang, P. Xu, J. Zhang, Z.-C. Hua
This study shows that FADD is critical for intestinal intraepithelial lymphocyte (IEL) development, particularly affecting CD8αα+ TCRγδ+ T cells, and its loss worsens colitis.
bioRxiv · May 3, 2018Immunology