Author

Z.-L. Shi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 2 Assay:proteomics· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1

Frequent Co-Authors

H. Yan· 3 shared P. Liu· 3 shared Q. Xiong· 3 shared X. Yu· 3 shared Y. Chen· 3 shared C. Liu· 2 shared C. Ma· 2 shared F. Tong· 2 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMicrobiology

H. Yan

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Engineering customized viral receptors for various coronaviruses

P. Liu, M. Huang, H. Guo, J. Si, Y. Chen, C. Wang, X. Yu, L. Shi, Q. Xiong, C. Ma, F. Tong, C. Liu, J. Chen, M. Guo, J. Li, , H. Yan

This paper develops a method to engineer customized viral receptors (CVRs) for various coronaviruses, enabling infection models for viruses lacking known receptors.

bioRxiv · Mar 3, 2024 · PreprintMicrobiology

Unconventional IFNω-like genes dominate the type I IFN locus and the constitutive antiviral responses in bats

R. Geng, Q. Wang, Y.-L. Yao, X.-R. Shen, J.-K. Jia, X. Wang, Y. Zhu, Q. Li, Z.-L. Shi, P. Zhou

This study identifies unconventional IFNω-like genes as dominant in bat type I IFN loci and constitutive antiviral responses, revealing pan-bat immune system characteristics.

bioRxiv · Feb 22, 2024 · PreprintImmunology

Sarbecovirus RBD indels and specific residues dictating ACE2 multi-species adaptiveness

J. Si, Y. Chen, M. Gu, Y. Sun, M. Huang, L. Shi, X. Yu, X. Yang, Q. Xiong, C. Ma, P. Liu, Z.-L. Shi, H. Yan

This study identifies RBM indel types in sarbecoviruses and their impact on ACE2 receptor usage across species, revealing how specific residues and structural features influence tropism and adaptiveness.

bioRxiv · Feb 11, 2024Microbiology

Multiple independent acquisitions of ACE2 usage in MERS-related coronaviruses

C.-B. Ma, C. Liu, Y.-J. Park, J. Tang, J. Chen, Q. Xiong, J. Lee, C. Stewart, D. Asarnow, J. Brown, M. A. Tortorici, X. Yang, Y.-H. Sun, Y.-M. Chen, X. Yu, , H. Yan

The paper identifies two European bat MERS-related coronaviruses that use ACE2 as their receptor, revealing a distinct binding mode and host tropism determinants.

bioRxiv · Oct 2, 2023Microbiology

Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin

P. Zhou, X.-L. Yang, X.-G. Wang, B. Hu, L. Zhang, W. Zhang, H.-R. Si, Y. Zhu, B. Li, C.-L. Huang, H.-D. Chen, J. Chen, Y. Luo, H. Guo, R.-D. Jiang, , Z.-L. Shi

This paper identifies and characterizes a novel coronavirus (nCoV-2019) causing a human pneumonia outbreak, showing its close genetic relationship to bat coronaviruses and its use of the ACE2 receptor for cell entry.

Nature · Feb 3, 2020Peer-reviewedMicrobiology