C. Stewart

Human coronavirus HKU1 recognition of the TMPRSS2 host receptor

This study determines the structure of HKU1 spike RBD bound to TMPRSS2, identifies host receptor usage determinants, and shows the role of antibodies and glycan shielding in neutralization.

Mapping immunodominant sites on the MERS-CoV spike glycoprotein targeted by infection-elicited antibodies in humans

This study maps immunodominant sites on MERS-CoV spike glycoprotein targeted by infection-elicited antibodies in humans, showing peak neutralizing activity against S1 and RBD epitopes.

Protein nanoparticle vaccines induce potent neutralizing antibody responses against MERS-CoV

This study develops MERS-CoV vaccines using a protein nanoparticle platform, showing they induce strong neutralizing antibodies and protect mice against MERS-CoV challenge.

A broadly generalizable stabilization strategy for sarbecovirus fusion machinery vaccines

This paper develops a stabilization strategy for sarbecovirus fusion machinery vaccines, showing broad reactivity and protection against SARS-CoV-2 variants.

Full-spike deep mutational scanning helps predict the evolutionary success of SARS-CoV-2 clades

This study uses deep mutational scanning to assess how mutations in SARS-CoV-2 spike proteins affect ACE2 binding, cell entry, and serum escape, linking these effects to clade growth rates.

Multiple independent acquisitions of ACE2 usage in MERS-related coronaviruses

The paper identifies two European bat MERS-related coronaviruses that use ACE2 as their receptor, revealing a distinct binding mode and host tropism determinants.

Broad receptor tropism and immunogenicity of a clade 3 sarbecovirus

This study characterizes the receptor tropism and antigenicity of a clade 3 sarbecovirus, identifying broad ACE2 usage and cross-neutralizing antibodies with implications for vaccine design.

Fusion crystallization reveals the behavior of both the 1TEL crystallization chaperone and the TNK1 UBA domain

The paper describes the use of TELSAM fusion crystallization to determine the structure of the TNK1 UBA domain and its interaction with polyubiquitin.

Decreasing the flexibility of the TELSAM-target protein linker and omitting the cleavable fusion tag improves crystal order and diffraction limits

This study shows that rigidifying the TELSAM-target protein linker and removing the SUMO tag improves crystal diffraction resolution.

FSHβ links photoperiodic signalling to seasonal reproduction in Japanese quail

This study identifies FSHβ as a key molecule linking photoperiodic signals to seasonal reproduction in Japanese quail by showing its expression precedes reproductive hormone changes and is regulated endogenously.

Interleukin-1α and Leukemia Inhibitory Factor Promote Extramedullary Hematopoiesis

This study identifies IL-1 and LIF as factors promoting EMH by activating splenic niche cells and inducing an inflammatory gene signature in HSPCs.

Establishing Novel Doxorubicin-Loaded Polysaccharide Hydrogel for Controlled Drug Delivery for Treatment of Pediatric Brain Tumors

This paper develops a doxorubicin-loaded polysaccharide hydrogel for targeted drug delivery in pediatric brain tumors, showing sustained drug release and cytotoxicity against medulloblastoma cells.

Imprinted antibody responses against SARS-CoV-2 Omicron sublineages

This study shows that hybrid immunity and vaccine boosters provide potent neutralizing activity against Omicron BA.1 and BA.2, while breakthrough infections induce nasal mucosal neutralization and identify an ultrapotent pan-variant antibody.

SARS-CoV-2 spike conformation determines plasma neutralizing activity

This study shows that vaccines encoding a prefusion-stabilized SARS-CoV-2 spike protein induce higher neutralizing antibody titers and better variant cross-neutralization compared to other vaccines or infection.

Genetic Subtypes of Smoldering Multiple Myeloma are associated with Distinct Pathogenic Phenotypes and Clinical Outcomes

This study identifies six genetic subtypes of smoldering multiple myeloma associated with distinct clinical outcomes and progression risks.

Delta breakthrough infections elicit potent, broad and durable neutralizing antibody responses

The paper examines antibody responses in Delta breakthrough infections, finding they are more potent, durable, and broad compared to vaccinated-only or infected-only individuals.

Dissemination and pathogenesis of toxigenic Clostridium perfringens strains linked to neonatal intensive care units and Necrotising Enterocolitis

This study identifies hypervirulent C. perfringens strains linked to NEC in preterm infants, showing their dissemination between hospitals and increased virulence.

TELSAM polymers accelerate crystallization of fused target proteins by stabilizing minimal crystal contacts and in the absence of direct inter-TELSAM contacts

This study shows that TELSAM polymers enhance protein crystallization by stabilizing minimal crystal contacts and enabling rapid crystallization without direct inter-TELSAM contacts.

Bacteriophage SP01 Gene Product 56 (gp56) Inhibits Bacillus subtilis Cell Division by Interacting with DivIC/FtsL to Prevent Pbp2B/FtsW Recruitment

This paper identifies gp56, a bacteriophage protein, as an inhibitor of Bacillus subtilis cell division by blocking recruitment of late division proteins through interaction with DivIC/FtsL.

Can individual and integrated water, sanitation, and handwashing interventions reduce fecal contamination in the household environment? Evidence from the WASH Benefits cluster-randomized trial in rural Kenya

This study evaluates the effectiveness of water, sanitation, and handwashing interventions in reducing fecal contamination in rural Kenyan households, finding limited success in reducing E. coli on child hands and toys.

A novel human enteroid-anaerobe co-culture system to study microbial-host interaction under physiological hypoxia

This paper introduces a co-culture system to study host-microbe interactions under physiological hypoxia using human intestinal enteroids and anaerobic bacteria.